General Terms and Conditions of Sale

Latest amendment: March 1, 2021

1. Scope of application

1.1 These general terms and conditions (hereinafter the “Agreement“) shall apply, without restriction or reservation, to all the offers and sales of products and services (hereinafter referred to respectively as the “Product(s)” and/or “Service(s)“) of YatiriBio, having its registered office at 10755 Scripps Poway Parkway, Suite 328 San Diego, CA 92131 (hereinafter referred to as “YatiriBio.” or the “Seller“), irrespective of the mode of communication used. This Agreement shall apply in particular to any and all offers or orders of Products or Services via the Seller’s website.

1.2 The Seller reserves the offer and sale of its Products and Services strictly for a professional public, a natural person, or a corporate body, for use exclusively for professional purposes (Business to Business), including laboratory research work. Any party that purchases Products or Services from the Seller in accordance with this Agreement (hereinafter referred to as the “Buyer“) represents, warrants and covenants that:

1.2.1 it is a member of the professional public and shall use the Products or Services exclusively for professional purposes in compliance with the terms and conditions of this Agreement;

1.2.2 it will not use the Products in, nor permit the Products to be used in any human clinical outcomes; and

1.2.3 it will not publicly share, reproduce, transmit Product information without the written consent of the Seller.

1.3 This Agreement contains the entire agreement of the parties with respect to its subject matter and supersedes all existing agreements and all other oral, written, or other communications between them concerning their subject matter. This Agreement shall not be modified by the Buyer in any way except pursuant to article 1.5.

1.4 The Buyer is requested to keep a paper or electronic copy of this Agreement for future reference.

1.5 No departure from this Agreement shall bind the Seller without its prior, explicit consent in writing. Accordingly, all other terms and conditions provided on the order form or any other document from the Buyer, such as its own general terms and conditions, shall not apply. Any departure that the Seller has accepted in accordance with this article 1.5 shall be valid only for the particular order to which this departure pertains and shall not apply automatically to subsequent orders or contracts.

1.6 The Seller and the Buyer may be willing to negotiate and enter in writing into another contractual document to govern their business relationship (the “Particular Terms and Conditions“). In the event of a contradiction between the terms and conditions of this Agreement and those of the Particular Terms and Conditions, the Particular Terms and Conditions will prevail (but then this Agreement shall only be superseded in respect of such Particular Terms and Conditions and in respect only of such specific matter).

1.7 Unless stipulated otherwise, for the purposes of this Agreement, the phrase “in writing” shall cover all written communication, whether by post, e-mail, or fax.

2. Offer and order

2.1 No verbal order by the Buyer shall be taken into consideration by the Seller unless it is confirmed by an order form in writing or by an order placed online on the Seller’s website in compliance with the instructions mentioned on said website.

2.2 Any order placed by the Buyer shall be binding for the Seller only if and of such time as it was confirmed in writing within five (5) working days by the Seller. In the absence of confirmation in writing within the stipulated period of five (5) working days, it shall be up to the Buyer to contact the Seller with which the offer was negotiated, or the order placed.

2.3 Any order confirmed in writing by the Seller shall be legally binding for the Seller and the Buyer. No cancellation or change by the Buyer of an order confirmed in writing by the Seller will be taken into consideration.

2.4 Unless stipulated expressly otherwise in the written offer of the Seller, any offer made by the Seller shall be valid for a maximum period of thirty (30) calendar days only.

3. Prices

3.1 The prices are quoted in US dollars exclusive of sales tax, VAT, and/or any other taxes, as applicable. Any increase in sales tax, VAT, and/or in any other taxes or any new tax imposed between the time that the order was placed, and the time of delivery shall be borne by the Buyer.

3.2 Unless stipulated otherwise in the Particular Terms and Conditions, the prices shall refer only to the supply of Products and Services described in the Particular Terms and Conditions, to the exclusion of all other works or services, and shall not include shipping and handling charges, duties and customs fees.

3.3 The Seller reserves the right to change the prices and specifications of Products and Services at all times without notice in the case of unavailability of raw materials or to reflect any increase in the cost to the Seller which is due to any factor beyond the control of the Seller such as, without limitation, any foreign exchange fluctuation, currency regulation, increase in the costs of labor, materials or other costs of manufacture, or modification of applicable laws. Such changes shall be applicable to any order placed after the initial appearance of said changes on the Seller’s website.

3.4 In the event of audit or inspection of Supplier’s facilities by the Buyer or by any regulatory authority, whatever if the audit or inspection is planned or unannounced, an audit fee of Two Thousand Five Hundred Dollars ($2,500.00) per day shall be charged to the Buyer.

4. Payment

4.1 Unless specified otherwise in the applicable offer of Seller, fifty percent (50%) of the total price shall be payable prior to the commencement of the ordered Services and the balance shall be invoiced following completion. Invoices shall be payable within thirty (30) calendar days of the date or dates specified on the invoice by wire transfer/check in the currency of the invoice. The payment must mention clearly the references mentioned on the invoice.

4.2 If an invoice is not paid on the date due, the Seller reserves the right to suspend deliveries of orders in progress (albeit already partially processed) or subsequent orders in such a case, until payment has been made in full. The Seller may require at all times that the price and shipping charges be paid prior to the delivery of Products or Services.

4.3 Once the period of payment has expired, the Buyer shall, automatically and without prior notice, be liable for interest for late payment at the lesser of the maximum rate permitted under applicable law or the rate of twelve percent (12%) per year, compounded daily.

4.4 Any invoice not paid when due shall moreover be increased, as of right and without notice, by a flat-rate compensation of ten percent (10%) of the outstanding amount, as compensation for additional administrative expenses incurred by the Seller in connection with late payment by the Buyer, with a minimum of fifty-five US dollars (USD $55) as applicable, without prejudice to any other compensation which the Seller would be entitled to claim in connection with such late payment.

4.5 If, in the Seller’s sole reasonable judgment, the Buyer’s credit rating deteriorates, then the Seller has the right, even after partial processing of the order, to demand such guarantees from the Buyer as the Seller shall, in its sole discretion, deem suitable for the proper performance of the commitments undertaken. If the Buyer refuses to comply, then the Seller shall be entitled to cancel all or part of the order.

4.6 The Buyer shall notify the Seller in writing of any complaint relating to the amounts invoiced within fifteen (15) calendar days after the date the invoice was delivered to the Buyer, otherwise the invoice shall be considered as being irrevocably and totally accepted by the Buyer.

5. Conditions of delivery

5.1 Unless explicitly stipulated otherwise in the Particular Terms and Conditions, delivery of the Products or Services shall be via an electronic portal.

5.2 Access to the electronic portal is granted to the Seller only and cannot be shared.

6. Delivery periods

6.1 Unless express guarantee is given in the Particular Terms and Conditions, the delivery periods shall not be strict deadlines. The Seller may be held liable only if the delay is extensive and attributable to gross negligence on its part.

6.2 A delay in delivery shall under no circumstances lead to the cancellation of the order by the Buyer.

7. Reservation of ownership

7.1 The Products and Services delivered shall remain the property of the Seller until the price has been paid in full, even in the case of transformation or incorporation of said Products or Services into other goods. If payment is not made on the date due, the Seller may require the Products or Services to be returned and the contract of sale to be canceled. No collateral or other security of any nature whatsoever shall be granted on these Products. The Buyer shall notify the Seller immediately in writing of any distrain by a third party on these Products or Services, or other goods in which the Products or Services may have been incorporated.

8. Approval

8.1 The Products or Services shall be deemed to be approved by the Buyer seven (7) calendar days at the latest after delivery unless a precise and detailed written complaint about non-compliance of the Products or Services is lodged by the Buyer with the Seller by registered letter prior to the expiry of this period.

8.2 The approval referred to in article 8.1 shall cover all the apparent defects, i.e. defects that the Buyer was able to detect at the time of delivery or within seven (7) calendar days that followed, by an attentive and rigorous inspection, and in particular defects relating to the characteristics and to the functioning of the Products and Services sold.

9. Limitation of liability

9.1 The Seller’s liability shall be limited strictly to the replacement of the non-compliant Products or Services or to the reimbursement of their price, at Seller’s sole election.

9.2 The Seller shall assume no liability other than that provided under article 9.1.

9.3 Accordingly, taking account of the specific nature of the Products and Services and the multiple possible applications, the Seller does not guarantee in particular that the Products and Services are adapted for the

intended application, and it shall be the Buyer’s responsibility to verify and to make sure that the Products and Services are appropriate and adequate for the intended application.

9.4 Except as provided under article 9.1, to the full extent permissible under the applicable legislation the Seller may not be held liable for any cost or liability arising from or in connection with Products or Services, including damages or accidents to persons, damages to goods other than the Products or Services sold, loss of earnings or profits, costs of cover, harm to reputation, or any other prejudice arising directly or indirectly from the Products or Services, and including defective Products or Services. IN NO EVENT SHALL THE SELLER BE LIABLE UNDER THIS AGREEMENT FOR ANY PUNITIVE, EXEMPLARY, INDIRECT, OR CONSEQUENTIAL DAMAGES, INCLUDING LOST PROFITS.

9.5 The Products or Services ordered by the Buyer are exclusively intended for laboratory research purposes and shall correspond to the safety standards in accordance with said research purposes. They shall not be used by the Buyer for any other purposes such as (the list is not exhaustive) diagnostic, therapeutic, or for medical devices. Without prejudice to the other provisions of this Agreement that limit or exclude the Seller’s liability, the latter shall accept no liability if the Buyer who ordered Products or Services intended exclusively for laboratory research uses said Products or Services for purposes other than for research.

10. Cancellation of the sale

10.1 The Seller shall be entitled to cancel the sale, as of right and without official notice, by apprising the Buyer of its intention by registered letter, in the event of serious breach on the part of the Buyer of its contractual obligations, in particular, if there is a delay in payment of an invoice of more than 30 (thirty) calendar days, or if it turns out that the Buyer will not fulfill or is at serious risk of not fulfilling one of its main obligations, even before the said obligation is due.

10.2 If the sale is canceled by virtue of the previous paragraph, the Buyer acknowledges that the extent of the Seller’s damages may be difficult to ascertain and, therefore, the Buyer shall be liable to the Seller for liquidated damages of fifty percent (50%) of the total selling price of (i) all Products and Services ordered by, but not yet delivered or provided to, the Buyer under this Agreement, and (ii) all Products and Services ordered by and provided to the Buyer during the previous twelve (12) months under this Agreement. The Seller nonetheless reserves the right to claim higher compensation, on the condition that it can provide proof of its loss.

11. Intellectual Property rights

11.1 The Seller does not guarantee that the sale and/or use of its Products and/or Services, alone or in combination with other products, or during a process, does not infringe the rights of third parties, including without limitation any patents, trademarks or copyrights of any third party.

11.2 The Seller shall remain the owner of intellectual property rights of which it is the holder or applicant. In particular, the order placed by the Buyer for Products or Services, its execution and the delivery of said Products or Services ordered, shall entail no assignment or transfer of, nor any license under, the Seller’s intellectual property rights, including any patents, trademarks or copyrights of the Seller. Notwithstanding the foregoing, Buyer will be the owner of intellectual property rights resulting or derived from Buyer’s intellectual property rights, including, without limitation, any such rights arising from Seller’s Products and Services (“Results Data”). Buyer hereby grants Seller the perpetual, worldwide royalty-free, non-exclusive right to use, modify, disclose and exploit such Results Data as part of its aggregated database and otherwise for Seller’s own business purposes.

11.3 The Buyer shall remain the owner of intellectual property rights of which it is the holder or applicant. In particular, the order placed for Products or Services by the Buyer shall not entail any assignment or transfer of the Buyer’s intellectual property rights, including any patents, trademarks, or copyrights of the Buyer.

11.4 Notwithstanding the foregoing, if, in order to carry out the order, the Seller has to use or implement intellectual property rights that are owned by the Buyer or that the Buyer claims to hold, then the Buyer hereby grants the Seller a royalty-free and worldwide license under such rights to use and to implement such intellectual property rights solely as needed to carry out the order.

11.5 The Buyer shall in no event decompile, disassemble, reverse engineer or attempt to reconstruct, identify or discover any source code, underlying ideas, techniques, or algorithms in the Products or Services by any means whatever, except as may be specifically authorized in advance by the Seller in writing.

12. Voidance

12.1 If any of the clauses of this Agreement were, for one reason or another, to be considered null and void, illegal or inapplicable, said clause shall be replaced by a valid, legal and applicable provision that reflects as well as possible the Seller’s original intent, and the validity, legality or applicability of the other clauses shall not be affected nor reduced as a result.

13. Export Control

13.1 Where applicable, the Buyer shall comply with all United States laws and regulations controlling the export of certain commodities and technical data, including without limitation all Export Administration Regulations of the United States Department of Commerce. Among other things, these laws and regulations prohibit, or require a license for, the export of certain types of commodities and technical data to specified countries. The Buyer hereby gives written assurance that it will comply with all United States export control laws and regulations, that it bears sole responsibility for any violation of such laws and regulations by itself, and that it will indemnify, defend, and hold the Seller harmless for the consequences of any such violation.

14. Indemnity

14.1 The Buyer shall defend, indemnify and hold the Seller, and the directors, officers, employees, and agents of either (collectively, the “Seller Indemnitees”), harmless from all losses, liabilities, damages, and expenses (including attorneys’ fees and costs) incurred as a result of any third party claim, demand, action or proceeding arising out of (i) any breach of this Agreement by the Buyer, and (ii) the use or implementation of intellectual rights that are owned by the Buyer and obtained by the Seller in accordance with article 11.4, including claims that the use or practice of such rights by the Seller under this Agreement infringes the rights of any third party.

14.2 The Seller shall defend, indemnify and hold the Buyer, and the directors, officers, employees, and agents of either (collectively, the “Buyer Indemnitees”), harmless from all losses, liabilities, damages, and expenses (including attorneys’ fees and costs) incurred as a result of any third party claim, demand, action or proceeding arising out of (i) any breach of this Agreement by the Seller, and (ii) the use or implementation of intellectual rights that are owned by the Seller and obtained by the Buyer, including claims that the use or practice of such rights by the Buyer under this Agreement infringes the rights of any third party.

14.3 Any Seller Indemnitee or Buyer Indemnitee claiming that it may be entitled to indemnity under article 14 shall give prompt written notice of such claim to the indemnifying party; provided that any delay in such notice shall not release the indemnifying party from its obligations under article 14 unless and to the extent such delay has materially prejudiced the defense of such claim. The indemnifying party shall retain competent counsel to defend such claim, and shall control the defense and settlement of such claim; provided, however, that (i) the indemnifying party shall not admit any fault, liability or wrong-doing on behalf of any Indemnitee, and (ii) the indemnifying party shall keep each Indemnitee informed of the status of such claim, including prompt notice of any settlement offers made by any third party claimant. An Indemnitee may, at its cost and expense, retain separate counsel in connection with the defense of any such claim.

15. Disclaimer of Warranty

15.1 Seller expressly warrants that the Products and Services delivered under this Agreement will be performed in accordance with: (i) its relevant documentation and this Agreement; (ii) a professional and workman-like standard; and (iii) industry-standard processes and procedures.

15.2 EXCEPT AS EXPRESSLY PROVIDED IN THIS AGREEMENT, ALL PRODUCTS AND SERVICES ARE PROVIDED TO THE BUYER (a) “AS IS” AND WITHOUT ANY WARRANTIES, EXPRESS OR IMPLIED, INCLUDING ANY WARRANTY OF MERCHANTABILITY, TITLE OR FITNESS FOR A PARTICULAR PURPOSE AND (b) WITHOUT ANY REPRESENTATION OR WARRANTY THAT THE USE OF PRODUCTS OR SERVICES WILL NOT INFRINGE ANY THIRD PARTY INTELLECTUAL PROPERTY RIGHTS, INCLUDING ANY PATENT, TRADEMARK OR OTHER RIGHT.

16. Applicable law – competent courts

16.1 If the Buyer places an order from the United States of America, this Agreement and the sales of Products or Services shall be governed by the laws of the State of California, the United States, irrespective of (i) the place of the delivery, (ii) the Buyer’s country/state of residence, or (iii) the conflict of laws principles applied by such country/state.

16.2 Any dispute relating, directly or indirectly, to the existence, interpretation, performance, or cancellation of the contract referred to in article 16.1 concluded by and between the Seller and the Buyer shall be referred exclusively to the United States District Court for the Southern District of California or in state court in San Diego, California, even in cases involving several defendants or in third party proceedings. The Buyer hereby waives any objection to such exclusive jurisdiction and on the basis that such courts may be an inconvenient forum.

16.3 If the Buyer places an order from any country in the world except the United States of America, this Agreement and the sales of Products or Services shall be governed by United States laws, irrespective of (i) the place of the delivery, (ii) the Buyer’s country/state of residence, or (iii) the conflict of laws principles applied by such country/state.

17. General

17.1 The Buyer may not assign this Agreement without the express prior consent of the Seller, except in connection with the sale or transfer of all of the Buyer’s assets to which this Agreement relates. The Seller may assign this Agreement without the consent of the Buyer.

17.2 No failure or delay by either party in exercising any right, power, or remedy under this Agreement will operate as a waiver of any such right, power, or remedy or of any other right, power, or remedy under this Agreement.

17.3 Nothing in this Agreement shall be deemed to create a joint venture or other joint relationship. Neither party shall have any actual, apparent, or implied authority as a result of this Agreement to create any obligation, express or implied, on behalf of the other party.

END OF AGREEMENT