Highlights Mass-spectrometry-based proteomic profiling of human cancers has the potential for pan-cancer analyses to identify molecular subtypes and associated pathway features that might be otherwise missed using transcriptomics Here, we classify 532 cancers, representing six tissue-based types (breast, colon,…
Highlights • Deep proteomic profiling reveals mechanistic differences among medulloblastomas • Proteomic-defined SHH subtypes do not differ in RNA expression • MYC phosphorylation events define a higher risk subset of group 3 patients • Inhibiting PRKDC may sensitize MYC-activated…
Highlights In the preceding decades, molecular characterization has revolutionized breast cancer (BC) research and therapeutic approaches. Presented herein, an unbiased analysis of breast tumor proteomes, inclusive of 9995 proteins quantified across all tumors, for the first time recapitulates BC…
Highlights Systematic identification of colon cancer-associated proteins and phosphosites Proteomics-supported neoantigens and cancer/testis antigens in 78% of the tumors Rb phosphorylation is an oncogenic driver and a putative target in colon cancer Glycolysis inhibition may render MSI tumors more…